[cflsystems]

I have no problem with this, with or without SpeedUp Tools colorbox files are loaded. But ... of course... I do not use conditions to load them so they load no matter what which may very well be the reason for colorbox not working for you with Speedup Tools enabled. There was similar issue with Flyout menus and cache so I would say this very well is the problem. Speedup Tools build the cache files once (every N hours per admin settings) and then use them so the cached files are not checked with every load for changes. I didn;t think about this when I posted the code above. I would suggest either don't use Speedup Tools or load colorbox files the regular way

<link css file />
<script.... />

That way they are not included in the cached files and will load with the conditional statement