The reason I went with Lytebox, is specifically because it doesn't have conflicts the way other shadowbox applications do. Other shadowboxes are typically based on JQuery, Mootools, or some other library, but the problem is, if you're mixing and matching different applications that all use those same libraries, you end up seeing a conflict somewhere.
Lytebox is completely standalone & self-contained. Seems much cleaner from an organizational standpoint
Cheers